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基础医学研究所

  • 姓 名:

    曹雪涛

  • 单 位:

    天美麻花星空基础医学研究所

  • 教职岗位:

    教授

  • 聘任时间:

    2018-07-01

  • 一级学科:

    基础医学

  • 二级学科:

    免疫学

  • 联系方式:

    caoxt@immunol.org

  • 导师风采链接:

个人介绍

曹雪涛,1964年生,籍贯山东,免疫学家,教授,博士生导师。1986年在第二军医大学获得临床医学专业学士学位。1990年在第二军医大学获得医学博士学位。毕业后留校任教,先后任讲师、教授、免疫学教研室主任、免疫学研究所所长、副校长。2005年当选中国工程院院士,2011年入职天美麻花星空基础医学研究所担任教授。先后当选为德国科学院院士、美国国家医学科学院院士、美国人文与科学院院士、法国医学科学院院士、英国医学科学院院士。


主要研究方向

主要从事天然免疫与炎症基础研究、肿瘤免疫治疗转化应用研究。发现数种新型免疫分子和细胞亚群,揭示免疫识别与应答调控新分子机制、提出免疫炎症消退新观点,鉴定了预测肿瘤转移标志物,建立了肿瘤免疫治疗新途径。


代表性成果

天美麻花星空

1. Yujia Wang#, Pin Wang, Yunkai Zhang, Junfang Xu, Zhiqing Li, Zemeng Li, Zhongcheng Zhou, Lin Liu, Xuetao Cao*. Decreased Expression of the Host Long-Noncoding RNA-GM Facilitates Viral Escape by Inhibiting the Kinase activity TBK1 via S-glutathionylation. Immunity, 2020, 53, 1168-1181. (IF=22.553)

2. Yang Liu#, Yuling You, Zhike Lu, Jiang Yang, Panpan Li, Lun Liu, Henan Xu, Yamei Niu, Xuetao Cao*. N6-methyladenosine RNA modification–mediated cellular metabolism rewiring inhibits viral replication.  Science, 2019, 365, 1171–1176. (IF= 41.845)

3. Lei Wang#, Mingyue Wen#, Xuetao Cao*. Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses. Science, 2019, 365,6454. (IF= 41.845)

4. Juan Liu#, Xiaomin Zhang, Kun Chen, Yujie Cheng, Shuxun Liu, Meng Xia, Yali Chen, Ha Zhu, Zhiqing Li, Xuetao Cao*. CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated Glycolysis. Immunity, 2019, 50, 600–615. (IF= 22.553)

5. Henan Xu#, Yan Jiang, Xiaoqing Xu, Xiaoping Su, Yang Liu, Yuanwu Ma, Yong Zhao, Zhongyang Shen, Bo Huang & Xuetao Cao*. Inducible degradation of lncRNA Sros1 promotes IFN-γ-mediated activation of innate immune responses by stabilizing Stat1 mRNA. Nature Immunology, 2019, 20,1621–1630. (IF= 20.479)

6. Hongyu Lin#, Minghong Jiang#, Lun Liu, Zongheng Yang, Zhongfei Ma, Shuo Liu, Yuanwu Ma, Lianfeng Zhang & Xuetao Cao*. The long noncoding RNA Lnczc3h7a promotes a TRIM25-mediated RIG-I antiviral innate immune response. Nature Immunology, 2019, 20, 812–823. (IF= 20.479)

7. Minghong Jiang#, Shikun Zhang#, Zongheng Yang, Hongyu Lin, Jun Zhu, Lun Liu, Wendie Wang, Shuo Liu, Wei Liu, Yuanwu Ma, Lianfeng Zhang, Xuetao Cao*. Self-Recognition of an Inducible Host lncRNA by RIG-I Feedback Restricts Innate Immune Response. Cell, 2018, 173, 906–919. (IF= 38.637)

8. Xiaoqing Xu#, Jia Xu, Jiacheng Wu, Ye Hu, Yanmei Han, Yan Gu, Kai Zhao, Qian Zhang, Xingguang Liu, Juan Liu, Bing Liu, Xuetao Cao*. Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response. Cell, 2018, 175, 1336–1351. (IF= 38.637)

9. Yanmei Han#, Qiuyan Liu, Jin Hou, Yan Gu, Yi Zhang, Zhubo Chen, Jia Fan, Weiping Zhou, Shuangjian Qiu, Yonghong Zhang, Tao Dong, Ning Li, Zhengping Jiang, Ha Zhu, Qian Zhang, Yuanwu Ma, Lianfeng Zhang, Qingqing Wang, Yizhi Yu, Nan Li, Xuetao Cao*. Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression. Cell, 2018, 173(3), 634–648. (IF=38.637)

10.Qicong Shen#, Qian Zhang#, Yang Shi, Qingzhu Shi, Yanyan Jiang, Yan Gu, Zhiqing Li, Xia Li, Kai Zhao, Chunmei Wang, Nan Li & Xuetao Cao*. Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation. Nature, 2018, 554, 123–127. (IF= 42.778)