王明荣，1956年生，籍贯安徽，肿瘤分子细胞生物学家，天美麻花星空肿瘤医院研究员，博士生导师。1977年考入安徽师范大学大学生物系，1982年获得学士学位。2005-2008年在皖南医学院组织胚胎学专业攻读硕士学位，从事细胞衰老研究。1991-1993年在法国克莱蒙大学攻读博士学位，从事膀胱癌遗传学研究。1993-1994年在克莱蒙大学进行博士后工作，进行肿瘤遗传学研究。1990年升为讲师，1995年获法国生物科学讲师资格，1996年升为副研究员，1997年破格升为研究员。

癌变分子机理及肿瘤分子标志：着重阐释肿瘤发生发展过程中细胞增殖、侵袭、凋亡的分子机制，发现癌前预警、肿瘤诊断及预后的分子标志，鉴定肿瘤预防、治疗的分子靶点。

天美麻花星空

1. Lin DC*, Wang MR*, Koeffler HP. Genomic and Epigenomic Aberrations in Esophageal Squamous Cell Carcinoma and Implications for Patients. Gastroenterology. 2018; 154(2):374-389. (IF= 20.773, C100)

2. Jiang YY#*, Lin DC#*, Mayakonda A#, Hazawa M, Ding LW, Chien WW, Xu L, Chen Y, Xiao JF, Senapedis W, Baloglu E, Kanojia D, Shang L, Xu X, Yang H, Tyner JW, Wang MR*, Koeffler HP. Targeting super-enhancer-associated oncogenes in oesophageal squamous cell carcinoma. Gut. 2017; 66(8):1358-1368. (IF= 16.658, C100)

3. Hao JJ#, Lin DC#*, Dinh HQ#, Mayakonda A#, Jiang YY#, Chang C, Jiang Y, Lu CC, Shi ZZ, Xu X, Zhang Y, Cai Y, Wang JW, Zhan QM, Wei WQ*, Berman BP*, Wang MR*, Koeffler HP. Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma. Nat Genet. 2016; 48(12):1500-1507. (IF= 31.616, C100)

4. Liu YZ, Yang H, Cao J, Jiang YY, Hao JJ, Xu X, Cai Y, Wang MR*. KIAA1522 is a novel prognostic biomarker in patients with non-small cell lung cancer. Sci Rep. 2016; 6:24786. (IF= 5.228, F1000)

5. Lin DC#*, Hao JJ#, Nagata Y#, Xu L#, Shang L, Meng X, Sato Y, Okuno Y, Varela AM, Ding LW, Garg M, Liu LZ, Yang H, Yin D, Shi ZZ , Jiang YY, Gu WY, Gong T, Zhang Y, Xu X, Kalid O, Shacham S, Ogawa S, Wang MR*, Koeffler HP. Genomic and molecular characterization of esophageal squamous cell carcinoma. Nature Genetics 2014; 46(5):467-73. (IF= 29.648, C100)

6. Shi ZZ, Shang L, Jiang YY, Hao JJ, Zhang Y, Zhang TT, Lin DC, Liu SG, Wang BS, Gong T, Zhan QM, Wang MR*. Consistent and differential genetic aberrations between esophageal dysplasia and squamous cell carcinoma detected by array comparative genomic hybridization. Clin Cancer Res. 2013; 19(21):5867-78. (IF=7.827)

7. Zhang Y, Du XL, Wang CJ, Lin DC, Ruan X, Feng YB, Huo YQ, Peng HY, Cui JL, Zhang TT, Wang YQ, Zhang HB, Zhan QM, Wang MR*. Reciprocal activation between PLK1 and Stat3 contributes to survival and proliferation of esophageal cancer cells. Gastroenterology. 2012; 142(3):521-530.e3. (IF=11.675, F1000)

8. Du XL, Hu H, Lin DC, Xia SH, Shen XM, Zhang Y, Luo ML, Feng YB, Cai Y, Xu X, Han YL, Zhan QM, Wang MR*. Proteomic profiling of proteins dysregulted in Chinese esophageal squamous cell carcinoma. J Mol Med. 2007; 85(8):863-75. (IF=5.157, F1000/C100)

9. Luo ML, Shen XM, Zhang Y, Wei F, Xu X, Cai Y, Zhang X, Sun YT, Zhan QM, Wu M, Wang MR*. Amplification and overexpression of CTTN (EMS1) contribute to the metastasis of esophageal squamous cell carcinoma by promoting cell migration and anoikis resistance. Cancer Res. 2006; 66(24):11690-9. (IF=7.656, C100)

10. Hu H, Xia SH, Li AD, Xu X, Cai Y, Han YL, Wei F, Chen BS, Huang XP, Han YS, Zhang JW, Zhang X, Wu M, Wang MR*. Elevated expression of p63 protein in human esophageal squamous cell carcinomas. Int J Cancer. 2002; 102(6):580-3. (IF=4.233, C100)