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阜外医院

  • 姓 名:

    汪一波

  • 单 位:

    天美麻花星空阜外医院

  • 教职岗位:

    准聘副教授

  • 聘任时间:

    2019-07-01

  • 一级学科:

    生物学

  • 二级学科:

    遗传学

  • 联系方式:

    yibowang@hotmail.com

  • 导师风采链接:

个人介绍

汪一波,1980年生,籍贯安徽,遗传学生物学家,阜外医院研究员,博士生导师。1997年考入浙江大学生物技术专业,2001年获得学士学位。2001年在中国协和医科大学遗传学专业攻读直博学位,从事心血管病易感基因的变异研究。2008年进入哈佛大学医学院进行博士后研究工作,主要研究疾病中翻译起始机制干预。2006年升为助理研究员。2010年为副研究员。2014年为研究员。


主要研究方向

研究方向:心血管病遗传学 以心脏血管疾病人群或患者为研究对象,包括动脉硬化、血管畸形、主动脉夹层、心肌病、高血压等,寻找可能参与的胚系和体细胞基因突变、CNV、融合基因等。对相关基因的功能或基因突变的功能进行研究,体外和动物水平阐明参与疾病发生发展的机制。对潜在的靶点进行临床转化,找到合适的靶向治疗方案。


代表性成果

天美麻花星空

1. Bing Cui#, Xiao Xiao#, Jin’e Wang, Hongrui Wang, Cunjin Wu, Yupeng Yan, Jun Zheng, JingJun Wang, Yuru Zong, Yu Zhang, Rutai Hui, A. Martin Gerdes, Yibo Wang*. Low THRB (thyroid hormone receptor beta) Promoter Methylation Levels in Peripheral Blood Leukocytes Induced By Systematic Inflammation Are Involved in Low Thyroid Hormone Function in Metabolic Syndrome. Hypertension. 2021;78:10051015. (IF=10.19)

2. Yupeng Yan#, Jin'e Wang, Liang Yu, Bing Cui, Hongrui Wang, Xiao Xiao, Yu Zhang, Jun Zheng, Jingjun Wang, Rutai Hui, Yibo Wang*. ANKRD36 Is Involved in Hypertension by Altering Expression of ENaC Genes. Circulation Research. 2021;129:10671081.(IF=23.213)

3. Tao Hong #, Xiao Xiao #, Jian Ren#, Bing Cui, Yuru Zong, Jian Zou, Zqi Kou, Nan Jiang, Guolu Meng, Gao Zeng, Yongzhi Shan, Hao Wu , Zan Chen, Jiantao Liang, Xinru Xiao, Jie Tang, Yukui Wei, Ming Ye, Liyong Sun, Guilin Li, Peng Hu, Rutai Hui, Hongqi Zhang, Yibo Wang*. Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations. Brain. 2021: 144; 26482658. (IF= 15.255)

4. Tao Hong#, Yupeng Yan#, Jingwei Li, Ivan Radovanovic, Xiangyuan Ma, Yang W. Shao, Jiaxing Yu, Yongjie Ma, Peng Zhang, Feng Ling, Shuchen Huang, Hongqi Zhang and Yibo Wang*. High prevalence of KRAS/BRAF somatic mutations in brain and spinal cord arteriovenous malformations. Brain. 2019;142(1):23-34.(IF= 13.501,C=100)

5. Mingli He#, Jin’e Wang#*, Na Liu, Xiao Xiao, Shan Geng, Pin Meng, Niu Ji, Yong’an Sun, Bingchao Xu, Yingda Xu, Xinyu Zhou, Guanghui Zhang, Xiaobing He, Zenglin Cai, Zaipo Li, Bei Wang, Bei Xu, Rutai Hui, Yibo Wang*. Effects of Blood Pressure in the Early Phase of Ischemic Stroke and Stroke Subtype on Poststroke Cognitive Impairment. Stroke. 2018;49(7):1610-1617. (IF=6.239)

6. Mingli He#, Jin'e Wang#, Ling Gong, Qing Dong, Niu Ji, Houxun Xing, Yuan Zhou, Sizhou Qin,Huizheng Wang, Huamin Zhang, Rutai Hui* and Yibo Wang*. Community-based stroke system of care for Chinese rural areas. Stroke. 2014;45:2385-2390. (IF=5.968)

7. Yibo Wang#*, Jing Xu#, Jinxing Chen, Xiaohan Fan, Yu Zhang, Weifeng Yu, Jibin Liu, Rutai Hui*. Promoter variants of VTN are associated with vascular disease. International Journal of Cardiology. 2013;168 (1): 163168. (IF=6.463)

8. Yibo Wang#*, Bin Lv#, Jinxing Chen, Yu Zhang, Fang Luo, Na Lu, Kai Sun, Zhihui Hou, Huili Cao, Irfan Zeb, Matthew Budoff and Rutai Hui*. Intramural coronary arterial course is associated with coronary arterial stenosis and prognosis of major cardiac events. Arterioscler Thromb Vasc Biol. 2013;33:439-444. (IF=6.640)

9. Yibo Wang#, Yi Zheng#, Weili Zhang, Hui Yu, Kejia Lou,Yu Zhang,Qin Qin, Bingrang Zhao, Ying Yang, Rutai Hui*.Polymorphisms of kdr gene are associated with coronary heart disease.Journal of the American College of Cardiology. Journal of the American College of Cardiology. 2007;50(8):760-767. (IF=10.345,C=100)

10. Yibo Wang#, Weili Zhang, Yuhui Zhang, Yuejin Yang, Lizhong Sun, Shengshou Hu, Jilin Chen, Channa Zhang, Yi Zheng, Yisong Zhen, Kai Sun, Chunyan Fu, Tao Yang, Jianwei Wang, Jing Sun, Haiying Wu, Wayne C. Glasgow and Rutai Hui*. VKORC1 haplotypes are associated with arterial vascular diseases. Circulation. 2006;113(12):1615-1621. (IF=11.786,C=100)