黄粤，1973年生，分子遗传学与干细胞生物学家，基础医学研究所研究员，博士生导师。1994年在吉林大学获分子生物学学士学位；1997年在中山大学获分子遗传学硕士学位； 2000年在中国协和医科大学获生化与分子生物学博士学位。留校在生化系工作，任助理研究员，主要从事成簇基因表达调控机制研究。2004年赴英国剑桥Sanger研究所进行博士后研究，主要从事基因纯合突变体文库构建和功能遗传筛选。2009年回国在医学遗传学系工作至今，2010年升为研究员。

利用多能干细胞和动物模型研究干细胞分化、个体发育和肿瘤形成过程中的内在分子机制,同时开展遗传病基因治疗的研究。近期在基于单倍体干细胞的功能遗传筛选、异倍体促进肿瘤发生发展及转移，等方面取得重要进展。

天美麻花星空

1. Zuo ZY#, Yang GH#, Wang HY#, Liu SY, Zhang YJ, CaiY, Chen F, Dai H, Xiao Y, Cheng MB*, Huang Y*, Zhang Y*. Klf4 methylated by Prmt1 restrains the commitment of primitive endoderm. Nucleic Acids Research, 50(4): 2005-2018, 2022. (IF=19.16)

2. Wang X#, Ping C#, Tan P#, Sun C, Liu G, Liu T, Yang S, Si Y, Zhao L, Hu Y, Jia Y, Wang X, Zhang M, Wang F, Wang D*, Yu J*, Ma Y*, Huang Y*. hnRNPLL controls pluripotency exit of embryonic stem cells by modulating alternative splicing of Tbx3 and Bptf. the EMBO Journal, 40 (4): e104729, 2021. (IF=11.598)

3. Zhang GZ#, Li XW#, Sun Y, Wang X, Liu G*, Huang Y*. A genetic screen identifiesEtl4-deficiency capable of stabilizing the haploidy in embryonic stem cells. Stem Cell Reports, 16 (1): 29-38, 2021. (IF=7.765)

4. Rui Yang#, Huanmin Wang#, Boxi Kang, Chen B, Shi Y, Yang S, Sun L, Liu Y, Xiao W, Zhang T, Yang J, Zhang Y, Zhu M, Ping Xu, Yongsheng Chang, Yuyan Jia*, Yue Huang*, CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development. Development.146(2): dev.169235, 2019. (IF=5.763)

5. Guang Liu#, Xue Wang#, Yufang Liu#, Meili Zhang, Tao Cai, Zhirong Shen, Yuyan Jia，Yue Huang*. Arrayed mutant haploid embryonic stem cell libraries facilitate phenotype-driven genetic screens. Nucleic Acids Research, 45(22): e180, 2017. (IF=11.147)

6. Meili Zhang#, Li Cheng, Yuyan Jia, Guang Liu, Cuiping Li, Shuhui Song, Allan Bradley, Yue Huang*. Aneuploid embryonic stem cells exhibit impaired differentiation and increased neoplastic potential. the EMBO Journal. 35(21): 2285-2300, 2016. (被选为封面论文，并配以 “News & Views” 专题评论) (IF=9.643)

7. Yanni Ma#, Nan Yao#, Guang Liu#, Dong L, Liu Y, Zhang M, Wang F, Wang B, Wei X, Dong H, Wang L, Ji S, Zhang J, Wang Y, Yue Huang*， Jia Yu*.  Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cells. the EMBO Journal. 34(3): 361–378, 2015. (IF=10.434)

8. Meili Zhang#, Yufang Liu#, Guang Liu#, Xin Li#, Yuyan Jia, Lihong Sun, Liu Wang, Qi Zhou，Yue Huang*. Rapidly Generating Knockout Mice from H19-Igf2 Engineered Androgenetic Haploid Embryonic Stem Cells. Cell Discovery. 1: e15031, 2015. (IF=4.462)

9. Yue Huang# *, Stephen J. Pettitt#, Ge Guo, Guang Liu, Meng Amy Li, Fengtang Yang，Allan Bradley*, Isolation of homozygous mutant mouse embryonic stem cells using a dual selection system. Nucleic Acids Research, 40(3): e21, 2012. (IF=8.808)

10. Wei Wang, Allan Bradley*, Yue Huang*. A PiggyBac transposon-based genome-wide library of insertionally mutated Blm-deficient murine ES cells. Genome Research. 19(4):667-73, 2009. (IF=10.176)